Research progress in the protective efficacy of human papillomavirus vaccines in males / 中华微生物学和免疫学杂志

Human papillomavirus (HPV) is one of the most common sexually transmitted pathogens. It can cause a variety of diseases such as condyloma acuminatum, anal cancer, penile cancer and oropharyngeal cancer in men, resulting in a high disease burden. With the development of society, the application of HPV vaccines in males has attracted more attention. Currently, there are many clinical trials and real-world research results of HPV vaccines applied to boys and men worldwide, and many countries have introduced HPV vaccination for underage boys into their national immunization programs. This article intended to review the research progress in the efficacy of HPV vaccines in male population.

Comparative evaluation of therapeutic efficacy and safety of 40% hydrogen peroxide versus 80% of trichloroacetic acid in genital warts

Background: Warts are a common manifestation of infection due to HPV, prevalence more common in developing world. No modality is 100% efficacious in the management of warts. Topical therapy is more preferred method by majority of patients. Trichloroacetic acid (TCA) solution is well established modality in treatment of genital warts. Hydrogen peroxide used in higher concentrations is a good cautery agent. Aim and Objectives: The study was conducted to evaluate and compare the therapeutic efficacy and safety of 40% hydrogen peroxide solution and 80% TCA solution in genital warts. Materials and Methods: Topical 40% hydrogen peroxide and 80% TCA were used in Group A (20 patients) and Group B (20 patients), respectively, for three sittings at 2 weeks interval. Results: About 65% of the patients in TCA and 55% patients in H2O2 group had significant improvement (Grade 4 and Grade 3) (P = 0.311). Descriptive statistical methods and 2-Chi-square relation were used for analyzing data with Statistical Package for the Social Sciences (SPSS) 21 (SPSS Inc., Chicago, IL, USA). Results: About 40% H2O2 and 80% TCA, both are cost-effective and easy to use modalities with 40% H2O2 having better safety profile as compared to 80% TCA. H2O2 group showed decrease in size of lesions 63.33% versus and TCA group 70% (p value 0.311) with 10% of TCA group patients having ulcer formation versus none of the patients having significant adverse effect in H2O2 group. Conclusion: We found both the modalities to be safe and effective. However, we recommend further studies should be carried out to assess the safety and efficacy with bigger sample size and control arms for both the groups topical 40% hydrogen peroxide solution and topical 80% TCA solution.

Prevalence of Sexually Transmitted Infections (STIs) among Adolescents Attending Genitourinary Medicine Clinic Hospital Kuala Lumpur between 2014 and 2018

Background@#Adolescents, who aged between 10 and 19 years old, comprise about 20% of the world’s population. They are vulnerable to acquisition of sexually transmitted infections (STIs). Here, we aim to determine the demography and pattern of STIs among adolescents attending Genito-Urinary Medicine (GUM) Clinic, Hospital Kuala Lumpur (HKL).@*Methods@#This is a retrospective study on all adolescents attending GUM clinic between 2014 and 2018. Data was obtained from case notes and further analysed.@*Results@#A total of 111 adolescents attended GUM clinic between 2014 and 2018. The mean age was 18 years (range 12-19). The male to female ratio was 2.26:1. All patients were Malaysian. Only 2 were foreign nationals. The majority were Malays (85.3%) followed by Indians (11%) and Chinese (3.7%). About 46.8% were still schooling, 28.8% were employed and 23.4% were unemployed. About 8.3% had a history of substance abuse. The majority (67.6%) were heterosexual, about 17.1% were homosexual and 3.6% were bisexual. Nearly 95% engaged in unprotected sex. Majority (46%) had casual sex. The most frequent presenting symptoms for male and female adolescents were discharge (43.2%) followed by swelling/growth (23.4%). About 83% had confirmed STIs. The most common STIs among the male were gonorrhoea (44.1%), genital warts (23.4%) and non-gonococcal urethritis (14.7%). The most common STIs among the female were herpes genitalis (50%), genital warts (33.3%) and syphilis (8.3%). Six patients were infected with the human immunodeficiency virus (HIV).@*Conclusion@#The most common STI among adolescents between 2014 and 2018 was gonorrhoea for male and herpes genitalis for female.

Factores asociados a la aceptabilidad de la vacuna contra el virus del papiloma humano, Huánuco, Perú / Factors associated with the acceptability of the human papillomavirus vaccine, Huanuco, Peru

INTRODUCCIÓN: El virus del papiloma humano (VPH) produce la infección viral transmitida por vía sexual más frecuente del mundo. Una estrategia para reducir las tasas de infección por este virus es la vacunación a mujeres jóvenes de entre 9 a 13 años, por lo que es imperioso asegurar el máximo grado de aceptabilidad a la vacuna. Objetivo: Determinar el nivel de conocimiento, las actitudes y creencias asociados a la aceptabilidad de la vacuna contra el VPH en los padres de Huánuco. MATERIAL Y MÉTODOS: Estudio transversal analítico en 168 padres. Las asociaciones se evaluaron con la prueba de χ2 con un 95% de confianza, p significativa < 0,05. RESULTADOS: La media de la edad fue 35,08 años. El 27,3% de padres no aceptaba la vacuna. Se encontró relación estadísticamente significativa entre el nivel de conocimiento medio-alto (p = 0,017), actitudes positivas hacia las vacunas (p < 0,001), ausencia de creencias (p < 0,001), religión católica (p = 0,002) y presencia de estudios en el grado de instrucción (p = 0,016) con la aceptabilidad hacia la vacuna. Aquellos padres en los que se evidenciaba la presencia de creencias tenían 6,56 veces más probabilidades de no aceptar la vacuna. CONCLUSIONES: Los factores asociados a la aceptabilidad de la vacuna contra el VPH son el nivel de conocimiento medio-alto, actitudes positivas hacia las vacunas, ausencia de creencias, religión católica y presencia de estudios en el grado de instrucción.

BACKGROUND: Human papillomavirus (HPV) produces the most frequent sexually transmitted viral infection in the world. A strategy to reduce infection rates for this virus is vaccination to young women between 9 and 13 years, so it is imperative to ensure the highest degree of acceptability to the vaccine. AIM: To determine the level of knowledge, attitudes and beliefs associated with the acceptability of the HPV vaccine in the parents of a rural and urban area of ​​the Huanuco. METHODS: Analytical cross-sectional study in 168 parents. The χ2 test was used to assess associations, with 95% confidence, p significant < 0.05. RESULTS: The mean age was 35.08 years, 67% had secondary education and 27.3% of parents did not accept the vaccine. A statistically significant relationship was found between the level of medium-high knowledge (p = 0.017), positive attitudes towards vaccines (p < 0.001), absence of beliefs (p < 0.001), Catholic religion (p = 0.002) and presence of studies in the degree of education (p = 0.016) with the acceptability towards the vaccine. Those parents whose beliefs were evidenced were 6.56 times more likely not to accept the human papillomavirus vaccine. CONCLUSIONS: The factors associated with the acceptability of the human papillomavirus vaccine are the level of knowledge, attitudes, beliefs, religion and the degree of instruction.

Awareness of human papilloma virus vaccine among medical interns in tertiary health centre

Background: Human Papilloma virus [HPV] infection is one of the most common sexually transmitted disease[STD] in the entire world. In India, HPV infections stands as one of the first few major cause of STD among both male and female adolescents and adults. However studies done in major centers reveals that awareness about this disease among the general population is poor. Aim of this study was the awareness of HPV and its preventive measures among medical interns who have recently completed their graduation and doing medical internship in a tertiary care centre.Methods: Total 100 participants were subjected to questionnaire study which has questions on basic knowledge about HPV and its preventive measures. The data were analyzed using Microsoft excel software.Results: Statically 98% of the study population was aware of HPV, whereas 78% were having knowledge about the vaccine availability for prevention of HPV and only 55% of them knew that the vaccine is available for use in India.Conclusions: Although majority of participants are having knowledge about HPV, the awareness on vaccine and its potentials are very poor. It is very important to put more emphasis on educating medical, nursing, para medical students and interns of various discipline on HPV infection and its preventive measures.

Prevalencia y manejo de condilomas en población consultante en Chile: estudio "DIACON" / Prevalence and management of condylomas in consulting population in Chile: "DIACON study"

Resumen Introducción: Los condilomas o verrugas genitales (VG) son la infección de transmisión sexual (ITS) más diagnosticada en los centros de ITS en Chile, pero no existen estadísticas poblacionales. Objetivos: Describir la prevalencia de VG en pacientes de 18-60 años que acuden a consulta ambulatoria de dermatología, ginecología y urología; características demográficas de los pacientes y prácticas de diagnóstico y tratamiento. Material y Métodos: A una muestra de especialistas chilenos estratificados por región, población y sexo de pacientes se les proporcionó un diario de registro y aplicó un cuestionario. Resultados: Prevalencia VG grupo total: 2,4%; en grupo etario 18-34 años: 3,7%; en grupo etario 35-60 años: 1,29% (p = 0,0000). La edad media de los pacientes con VG fue 29,4 años en mujeres y 32,7 años en hombres (p = 0,019); la distribución por edad fue diferente según sexo y sistema de salud. La inspección visual fue el método diagnóstico más frecuente y la crema de imiquimod el tratamiento más común. Hubo diferencias en el uso de herramientas diagnósticas y terapéuticas según sexo del paciente, especialidad del médico y sistema de salud. Conclusiones: Existe una alta prevalencia de VG, que debería ser tomada en cuenta para planificar las intervenciones de salud pública para abordar este problema.

Introduction: Condylomas or genital warts (GW) are the most frequently diagnosed sexually transmitted infection (STI) in STI centers in Chile, but there are no population statistics available. Objectives: To describe the prevalence of GW in patients from 18-60 years of age who attend outpatient dermatology, gynecology and urology practice; the demographic characteristics of the patients and the diagnostic and treatment tools. Methods: A sample of Chilean specialists stratified by region, population and gender of patients was provided with a logbook and answered a questionnaire. Results: The GW prevalence was 2.44% for the whole group; 3.76% for the 18-34 age group and 1.29% for the 35-60 years group (p = 0.0000). The average age of patients with GW was 29.4 years in women and 32.7 years in men (p = 0.019). The distribution by age was different according to gender and health system. Visual inspection was the most frequent diagnostic method used and imiquimod cream the most common treatment, however, there were differences in the use of diagnostic and therapeutic tools according to the patient's gender, specialty of the doctor and health system. Conclusions: The high prevalence of GW confirmed the need and importance of public health interventions to address this problem.

Management Of Genital Warts Through Ayurveda-a Case Report

External genital warts or Condyloma Acuminata is caused by the Human Papilloma Virus subtypes 6 and 11. According to Ayurveda it can be diagnosed as Yoni Arsa. This case report presents a 51 yr old female with the complaints of per vaginal discharge, itching and appearance of progressively increasing number of lesions in the vulva for 6 months. The pathological diagnosis of the vulvar lesion specimen was Condyloma Acuminata. Patient was treated with internal administration and external application of Ayurvedic medicines. Considerable relief for the condition was noted and the follow up visits confirmed the non recurrence of the disease. Ayurvedic interventions can be considered as minimal invasive and cost effective in the management of genital warts.

Condilomatosis genital en embarazadas, experiencia del manejo y tratamiento en la Maternidad Mariana de Jesús / Genital condylomatosis in pregnants, experienceof handling and treatment in Maternity Mariana de Jesus

Introducción: La condilomatosisgenital o verruga genital es una de las manifestaciones clínicas más común de infección del virus del papiloma humano (VPH), predominantemente causadas por los genotipos VPH-6 y -11. Durante el embarazo, el incremento en los niveles de las hormonas esteroides modifica el sistema inmune de la madre contribuyendo a la "tolerancia" del feto, pero disminuye la capacidad de eliminar infecciones, incluido el VPH. El presente estudio plantea determinar el comportamiento de la condilomatosis genital en gestantes atendidas en la Maternidad Mariana de Jesús desde 2016 a 2017. Materiales y métodos: Es un estudio longitudinal, observacional, retrospectivo, en 84 gestantes que fueron atendidas entre el 1 de enero de 2016 al 30 de septiembre de 2017. Resultados: En las 84 gestantes analizadas se pudo observar quela mayoría de las pacientes con condilomas tiene de 20 a 25 años de edad; su primera relación sexual fue entre los 17 a 19 años; existiendo mayor número de gestantes multíparas, y que han tenido más de 2 parejassexuales.

Introduction: Genital condylomatosisor genital wart is one of the most common clinical manifestations of human papilloma virus (HPV) infection, predominantly caused by HPV-6 and -11 genotypes. During pregnancy, increased levels of steroid hormones modify the mother's immune system contributing to the "tolerance" of the fetus, but decrease the ability to eliminate infections, including HPV. The present study proposes to determine the behavior of genital condilomatosis in pregnant women attended in the Mariana de Jesus Maternity from 2016 to 2017. Materials and Methods: It is a longitudinal, observational, retrospective study in 84 pregnant women who were attended between January 1, 2016 to September 30, 2017. Results: In the 84 pregnant women analyzed it was possible to observe that the majority of patients with condylomas are between 20 and 25 years of age; her first sexual relationship was between 17 and 19 years old; There is a greater number of multiparous pregnant women, and they have had more than 2 sexual partners. The condylomas were presented individually, preferably being accumulated, predominantly in the second trimester of pregnancy. Conclusion: Although the greatest effort of studies is carried out in high-risk HPV, it is important to carry out studies that show the reality of the condylomas caused by low-risk HPV, mainly focusing on avoiding maternal-neonatal transmission.

Incidence, psychosocial burden, and economic impact of genital warts in Mexico / Incidencia, carga psicosocial e impacto económico de las verrugas genitales en México

Abstract: Objective: To estimate the burden of genital warts (GW) in Mexico. Materials and methods: We estimated the annual incidence of GW based on data reported by specialist physicians. We also assessed GW treatment practices, the average cost of treatment, and the psychosocial burden of GW among patients. Results: The annual incidence of GW in Mexico was estimated to be 547 200 cases. Treatment procedures vary by specialist and patient gender. The estimated annual cost was $195 million USD. The psychosocial impact of GW was slightly greater in males than females. Conclusions: This is the first evaluation of the burden of GW in Mexico. Our data suggest that GW are common, with significant health-related costs and psychosocial impact.

Resumen: Objetivo: Estimar la carga por verrugas genitales (VG) en México. Material y métodos: Estimamos la incidencia anual de VG, con base en información proporcionada por médicos especialistas y el manejo de las VG, así como el costo promedio del tratamiento y la carga psicosocial de las VG. Resultados: La incidencia anual de VG en México fue de 547 200 casos. Los tratamientos variaron según la especialidad y el sexo del paciente. El costo anual por VG fue de $195 millones de dólares estadounidenses. El impacto psicosocial de las VG es ligeramente mayor en hombres que en mujeres. Conclusiones: Esta es la primera evaluación de la carga de VG en México. Los datos sugieren que las VG son frecuentes, tienen costos relacionados con salud e impactos psicosociales significativos.

Incidence of external genital lesions related to human papillomavirus among Mexican men. A cohort study / Incidencia de lesiones genitales externas relacionadas con el virus del papiloma humano entre hombres mexicanos. Un estudio de cohorte

Abstract: Objective: To determine external genital lesion (EGL) incidence -condyloma and penile intraepithelial neoplasia (PeIN)- and genital HPV-genotype progression to these EGLs. Materials and methods: Participants (healthy males 18-74y from Cuernavaca, Mexico, recruited 2005-2009, n=954) underwent a questionnaire, anogenital examination, and sample collection every six months; including excision biopsy on suspicious EGL with histological confirmation. Linear array assay PCR characterized 37 high/low-risk HPV-DNA types. EGL incidence and cumulative incidence were calculated, the latter with Kaplan-Meier. Results: EGL incidence was 1.84 (95%CI=1.42-2.39) per 100-person-years (py); 2.9% (95%CI=1.9-4.2) 12-month cumulative EGL. Highest EGL incidence was found in men 18-30 years: 1.99 (95%CI=1.22-3.25) per 100py. Seven subjects had PeIN I-III (four with HPV16). HPV11 most commonly progresses to condyloma (6-month cumulative incidence=44.4%, 95%CI=14.3-137.8). Subjects with high-risk sexual behavior had higher EGL incidence. Conclusion: In Mexico, anogenital HPV infection in men is high and can cause condyloma. Estimation of EGL magnitude and associated healthcare costs is necessary to assess the need for male anti-HPV vaccination.

Resumen: Objetivo: Determinar incidencia de lesiones genitales externas (LGE) -condiloma y neoplasia intraepitelial del pene (NIP)- y progresión de genotipos de VPH a LGE. Material y métodos: Se aplicaron cuestionarios, examen anogenital y recolección de muestras cada seis meses a hombres sanos (18-74 años, de Cuernavaca, México, reclutados 2005-2009, n=954) con biopsia y confirmación histológica. Se caracterizaron 37 tipos de ADN-VPH; se calculó incidencia de LGE (cumulativa con Kaplan-Meier). Resultados: Incidencia de LGE=1.84 (IC95%=1.42-2.39) por 100-persona-años (pa); 2.9% (IC95%=1.9-4.2) LGE acumulativa a 12 meses. Mayor incidencia de LGE entre hombres 18-30 años; 1.99 (IC95%=1.22-3.25) por 100pa. Siete sujetos tuvieron NIP I-III. VPH-11 más comúnmente progresa a condiloma (incidencia acumulativa a seis meses=44.4%, IC95%=14.3-137.8). Los sujetos con comportamiento sexual de alto riesgo tuvieron mayor incidencia de LGE. Conclusiones: En México la infección anogenital con VPH es alta y puede causar condiloma. La estimación de magnitud de LGE y los costos sanitarios asociados se necesita para evaluar la necesidad de vacunación contra VPH en hombres.

Paciente con vih y co-infectado por el hpv: un estudio de caso

RESUMEN Actualmente las infecciones causadas por el virus y el VPH se consideran un gran problema de salud pública mundial. El objetivo fue analizar el impacto del VIH y el VPH en la vida familiar, sexual y social; Identificar los diagnósticos y relacionar la carga viral y CD4 y evaluar la adhesión a la TARV. Paciente del sexo masculino, 52 años con diagnóstico de VIH y VPH, fue posible identificar los principales diagnósticos multidisciplinarios de acuerdo con la NANDA, siendo un total de 11 diagnósticos. Se sugiere una mirada más reflexiva del médico y su equipo multidisciplinario en lo que se refiere a la salud pública, pues no basta con tratar al paciente infectado, es necesario que el paciente reciba orientaciones sobre el proceso salud-enfermedad del paciente VIH con coinfección por el VIH HPV con el fin de promover la prevención secundaria

ABSTRACT Currently, infections caused by HIV and HPV are considered a major public health problem worldwide. The objective was to analyze the impact of HIV and HPV on family, sexual and social life; To identify the diagnoses and to relate the viral and CD4 load and to evaluate the adherence to ART. A 52-year-old man with a diagnosis of HIV and HPV was able to identify the main multidisciplinary diagnoses according to NANDA, with a total of 11 diagnoses. It is suggested a more reflective look by the physician and his multidisciplinary team regarding public health, since it is not enough to treat the infected patient, it is necessary that the patient receive guidance about the health-disease process of the HIV patient with co-infection by the HPV in order to promote secondary prevention

Relationship between circumcision and human papillomavirus infection: A systematic review and meta-analysis / 亚洲男科学杂志(英文版)

Male circumcision (MC) is reported to reduce human papillomavirus (HPV) prevalence in men. However, the efficacy remains imprecise. The aim of this study was to conduct a systematic review and meta-analysis to assess the relationship between MC and genital HPV infection and genital warts. PUBMED, EMBASE, and Web of Science were searched from inception to March 22, 2015. We identified 30 papers, including a total of 12149 circumcised and 12252 uncircumcised men who were evaluated for the association of circumcision with genital HPV or genital warts. Compared with men who were not circumcised, circumcised men may have had significantly reduced odds of genital HPV prevalence (odds ratio [OR]: 0.68; 95% confidence interval [95% CI]: 0.56-0.82). There was no significant association between MC and genital HPV acquisition of new infections (OR: 0.99; 95% CI: 0.62-1.60), genital HPV clearance (OR: 1.38; 95% CI: 0.96-1.97), and prevalence of genital warts (OR: 1.17; 95% CI: 0.63-2.17). This meta-analysis suggests that circumcision reduces the prevalence of genital HPV infections. However, no clear evidence was found that circumcision was associated with decreased HPV acquisition, increased HPV clearance, or decreased the prevalence of genital warts.

The psychosocial and economic burden of genital warts among women assisted in sixsexual and reproductive health clinics in Brazil / A carga psicossocial e econômica de verrugas genitais em mulheres atendidas em seis clínicas de saúde sexual e reprodutiva no Brasil

Introduction: World Health Organization estimates that 291 million women worldwide will have a human papillomavirus infection. Treatment for genital warts brings discomfort and may be stressful. Objective: The objectives are to estimate the psychological burden of genital warts and to estimate its economic and burden in six reproductive health clinics in Brazil. Methods: Women visiting BEMFAM'S Clinics form January 2012 until March 2013 filled a self-administrated questionnaire based on psychometric scale. The economic burden was measured with a retrospective study of medical chart review of patients assisted from January 2009 to December 2010. Results: A total of 122 individuals filled the psychosocial questionnaire. Women with normal Pap smear presented lower scores of worries and concerns about gynecological health than women with cervical intraepithelial neoplasia (CIN) or GW and higher scores of satisfaction with sexual life than women with CIN or GW. Feelings of anxiety and surprise with the the last exam were higher in GW group than for normal Pap smear and CIN goups. Each GW episode lasted on average 132 days, had 6 medical visits and costs US$139. Conclusion: The economic burden of GW is closely related to psychosocial burden, and the use of health services after a GW episode should be considered in future resaech. The study of indirect costs is important, considering the number if visits per episode of GW. Additional studies are needed and can help in the advocacy efforts for a comprehensive prevention programs in Brazil.

Introdução: A Organização Mundial de Saúde estima que 291 milhões de mulheres serão infectadas pelo Papilomavírus humano. O tratamento das verrugas genitais pode ser desconfortável e estressante. Objetivo: Estimar a carga psicossocial das verrugas genitais (VG); e estimar a carga econômica das verrugas genitais entre mulheres atendidas em seis clínicas de saúde reprodutiva. Métodos: Voluntárias atendidas nas Clínicas da BEMFAM entre 2010 e 1013 preencheram um questionário baseado na escala psicométrica. A carga econômica foi medida através da análise de prontuários de pacientes atendidas entre 2009 e 2010. Resultados: O questionário psicossocial foi preenchido por 122 sujeitos. Mulheres com Papanicolaou normal apresentaram menores índices de preocupação quanto à saúde ginecológica e maiores índices de satisfação com a vida sexual do que mulheres com neoplasia intraepitelial (CIN) ou VG. Sentimentos de ansiedade e surpresa com o resultado dos exames foram mais observados entre mulheres com verrugas genitais do que nas com Papanicolaou normal ou CIN. Em média, cada episódio de verruga genital durou 132 dias, demandou seis visitas médicas, e custou US$139. Conclusão: Houve relação entre a carga econômica das VG. O presente estudo reforça a importância da análise dos custos indiretos, considerando o número de visitas por episódio de VG. Estudos adicionais podem fortalecer os esforços para programas abrangentes de prevenção no Brasil.

Intervención educativa sobre el condiloma acuminado en mujeres en edad fértil / Educational intervention on condyloma acuminata in childbearing-age women

Introducción: el condiloma acuminado producido por el virus del papiloma humano (VPH) es una infección de transmisión sexual frecuente en las mujeres en edad fértil. Objetivo: incrementar el nivel de conocimiento de la infección por VPH. Métodos: se realizó un estudio de intervención educativa en mujeres en edad fértil atendidas en la consulta de ginecología del Hospital Centenario de la provincia de Camagüey...

Introduction: condyloma acuminatum caused by human papilloma virus (HPV) is a common sexually transmitted infection in women of childbearing age. Objective: to increase the level of knowledge of HPV infection. Methods: An educational intervention study was conducted in women of childbearing age assisted at the Gynecology Hospital Centenario in Camaguey province. The universe consisted of 32 patients treated in this consultation from 1. January 1st 2009 to January 31st, 2010. An initial questionnaire was given to those patients who expressed their consent in relation to knowledge about ways of infection, clinical manifestations and complications...

Aplicación Intralesional del Interferón alfa 2bHr cubano (Heberon Alfa R®) en el tratamiento de las verrugas genitales / Intralesion application of the Cuban 2bHr Alfa-Interferon (Heberon Alfa R®) in the treatment of genital warts

Introducción: la condilomatosis genital es la expresión clínica más frecuente de del virus del papiloma humano. De las alternativas de tratamiento existentes, no hay una de elección y absolutamente eficaz. Objetivo: describir la seguridad y el efecto del Interferón alfa recombinante, en el tratamiento de las verrugas genitales. meses mediante la curva de Kaplan-Meier. ..

Introduction: the genital condyloma is the more frequent clinical expression or the human papilloma virus. From the available alternative of treatment there is not one of election and totally effective. Objective: to describe the safety and the effect of recombinant alfa-Interferon in treatment of genital warts. Methods: a quasi-experimental study was conducted in 216 women and in 111 men. The above mentioned Interferon was applied in the basement of warts at a dose of 10 millions of international units weekly during 8-16 weeks...

VPH / HPV

Actualmente la Administración de drogas y Alimentos (FdA) de estados unidos aprobó dos vacunas para prevenir la infección por vPh (virus de Papiloma humano): Gardasil® (vacuna tetravalente) y cervarix ® (vacuna bivalente). Ambas vacunas son muy efectivas en la prevención de infecciones persistentes por los tipos 16 y 18 de vPh, dos de los vPh de “alto riesgo” que causan la mayoría (70%) delos cánceres de cuello uterino y en menor porcentaje de cáncer de ano y pene. Gardasil® impide también la infección por los tipos 6 y 11 de vPh, los cuales causan prácticamente todas (90%) las verrugas genitales. se presenta un resumen de la inmunogenicidad, eficacia, indicaciones, modo de empleo y presentaciones comerciales de estas dos vacunas

the Food and drug Administration (FdA) of usA licensed two vaccines for the prevention of vPh (human Papillomavirus) infection: Gardasil® (quadrivalent vaccine) and cervarix® (bivalent vaccine). Both vaccines are very effective in the prevention of persistent infection by serotypes 16 and 18 of vPh, two of the “high risk” vPh, which cause 70% of cervical cancers and in low percentages anal and penile cancers. Gardasil® prevents infection by serotytpes 6 and 11, which cause almost all (90%) of genital warts.this review presents the immunogenicity, efficacy, recommendations, doses, administration and commercial presentation of bothvaccines

Tratamento cirúrgico do condiloma vulvar: relato de caso / Surgical treatment of vulvar condyloma: a case report

Introdução. As lesões associadas ao papilomavírus humano, excluídas as neoplasias intraepiteliais cervicais, são mais prevalentes em mulheres com o vírus da imunodeficiência humana tipo 1. Apesar de opiniões radicais a favor do tratamento cirúrgico, em quase todos os casos com lesões, a conduta terapêutica mais adequada deve ser individualizada.Relato do caso. Mulher de 25 anos, com o vírus da imunodeficiência humana, com extensa lesão condilomatosa vulvar, com dez centímetros de maior diâmetro e um ano de evolução. Optou-se por exérese da lesão com cirurgia realizada por meio de ondas de radiofrequência. À avaliação, noventa dias após a cirurgia, não houve sinais de recidiva e não foram vistas lesões de vagina ou de colo uterino. O exame anatomopatológico confirmou a hipótese de diagnóstico de condiloma acuminado. Discussão. O tratamento cirúrgico de condilomas em mulheres imunodeprimidas constitui opção de escolha para diminuir a transmissibilidade da infecção pelo papilomavírus humano e o risco de carcinoma vulvar, aparentemente aumentado nessas pacientes. Além disso, pretende eliminar as manifestações clínicas, amenizar a carga psicológica decorrente do estigma social e melhorar o aspecto estético da enferma.

Introduction. Lesions associated with human papillomavirus, excluding intraepithelial cervical neoplasias, are most prevalent among women infected with type 1 human immunodeficiency virus (HIV-1). Despite of radical opinions favoring surgical treatment for most these lesions, the most adequate therapeutic conduct should be planned on an individual basis. Case report. A 25-year-old human papillomavirus infected woman with an extensive vulvar condylomatous lesion of one year duration measuring 10 cm in its widest diameter was investigated. Exeresis of the lesion was performed by radiofrequency waves surgery. The evaluation ninety days after surgery showed no signs of recurrence, and no lesions were observed in the vagina or in the uterine cervix. Anatomopathological examination confirmed the diagnostic hypothesis of condylomata acuminatum. Discussion. Surgical treatment of condylomata in immunodepressed women is a question of choice in order to reduce the transmissibility of human papillomavirus infection and the risk of vulvar carcinoma, which is apparently increased in these patients. In addition, the aim of surgery is to eliminate symptoms, relieve the psychological burden due to the social stigma and to improve the aesthetic appearance of the patient.

Detection of HPV Types and Neutralizing Antibodies in Women with Genital Warts in Tianjin City,China / 中国病毒学·英文版

The serum samples and corresponding cervical swabs were collected fi'om 50 women with genital warts from Tianjin city,China.The neutralizing antibodies against HPV-16,-18,-58,-45,-6 and-11 in serum samples were tested by using pseudovirus-based neutralization assays and HPV DNAs in cervical swabs were also tested by using a typing kit that can detect 21 types of HPV.The results revealed that 36%(18/50)of sera were positive for type-specific neutralizing antibodies with a titer range of 160-2560,of which 22%(11/50),12%(6/50),10%(5/50),4%(2/50),4%(2/50)and 2%(1/50)were against HPVs-6,-16,-18,-58,.45 and-11,respectively.Additionally,60%(30/50)of samples were HPV DNA-positive,in which the most common types detected were HPV-68(18%),HPV-16(14%),HPV-58(12%),HPV-33(8%)and HPV-6,HPV-11,HPV-18 and HPV-52(6% each).The concordance between HPV DNA and corresponding neutralizing antibodies was 56%(28/50)with a significant difference(P＜0.05).The full-length sequences of five HPV types(HPV-42,-52,-53,-58 and-68)were determined and exhibited 98%-100% identities with their reported genomes.The present data may have utility for investigating the natural history of HPV infection and promote the development of HPV vaccines.